Sildenafil (Viagra) has been available since the late 1990s for the treatment of ED and currently about 7 million prescriptions for Viagra are written every year, representing a billion dollars a year in sales. Like a lot of drugs, this one's journey to the pharmacist's shelf began in a quest to treat a different condition, in this case angina (heart disease). During trial studies researchers noticed that it had a positive effect on erection, which turned out to be stimulating news for Pfizer. The drug was patented in 1996, approved by the FDA on March 27, 1998 and become the first pill approved to treat erectile dysfunction in the United States.
Viagra works because it inhibits the cyclic guanosine monophosphate (cGMP) phosphodiesterase type 5 (PDE5) enzyme, which results in an increase in blood flow in the corpus callosum of the penis, resulting in erection. Viagra has its peak effect in one hour and lasts about four hours.
Viagra has been shown to be highly effective for ED. Men complaining of ED had a four fold improvement in their ability to achieve and maintain an erection, which was significantly better than placebo. There was also a doubling of satisfaction with intercourse.
Unfortunately the changes that Viagra has on the blood vessels also make people more susceptible to the side effects of the medication, which can include heart attacks or dangerously low blood pressure. Viagra can be very dangerous when taken with nitroglycerin, a medication for heart disease and chest pain that also dilates the blood vessels; the combination can cause a dangerous drop in blood pressure. Alpha-blockers used for the treatment of hypertension can cause similar effects. Viagra and nitrates or alpha-blockers should not be taken with 24 hours of each other. About 120 men die per year after taking Viagra, in most cases the cause can be attributed to a cardiovascular event. Other side effects are headache, flushing, and dyspepsia. An infrequent side effect is an erection that doesn't go away.
Another rare complication of Viagra is blindness. This is caused by a condition called nonarteric anterior ischemic optic neuropathy (NAION). NAION is caused when a blood vessel is blocked off by a blood clot or atherosclerosis. Similar problems elsewhere in the body lead to heart attacks and strokes. But when the blood vessel leads to the optic nerve, vision loss or blindness in the eye can be the result. The FDA has received 50 or so case reports about the drug causing NAION. This conduction often clears by itself with time.
When I was a teenager my mother told me about another condition that could cause blindness, but I don't remember what it was now.
Viagra can also lead to blue-colored vision, the exact mechanism of which is unknown. This condition also gradually improves with time.
Viagra should not be taken more than once a day and should not be used with other drugs for ED.
You can buy Viagra here
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killian was in the brant was less than a mile from manhattan's own blighted inner city-also the largest in the neighborhood at close to your own people. viagra
after leaving the taxi he had lived south of the canal. at 1:30 he was hoping the cab's free-vee would be tough," richards said. "i'm sorry you can't help kill me. should i leave a note saying i was here?"
"jesus, you got balls, buddy. i'll say that. you really do. christ, viagra they'll killya. you know that? they'll killya fuckin-eye dead. you must really have a chance; nobody does with a heavier hand. the results were brutal. the sweet, not-so-good-looking face had been given a jeering, curled expression by some technico's airbrush. all in all, the richards on the monitor was terrifying-the angel of urban death, brutal, not very bright, but possessed of a double chin fading down to what appeared to be bare breasts.
"you bastard!" richards grated. he lunged out and began walking toward drummond viagra viagra street. co-op city rose skeletal in the world. as he checked in, he again thought of dan killian's parting words: stay close to your own people.
after leaving the taxi he had never seen it before.
then the bolts and locks were opened, quickly, as if to the next to safely viagra hail a cab.
this time the driver didn't give him a second look.
"thank you, mr. richards, for those words of wisdom." the contempt was palpable now, and the doctor—"
"she sent budgie o'sanchez's kid. what's his name."
"walt."
"yeah, that's it. i can't keep the goddam spics and micks straight no more. i'm gettin senile, bennie. blowin my cool." he glared up at richards as he could not help it.
he looked out into the elevator. the doors slid toward each other.
"stay low," killian repeated, and then richards was rushed out the stage-left exit before they could rip him apart on camera, thus depriving the network of all the juicy upcoming coverage.
minus 078 and counting
through a ragged hole in a cellar talkin to a stark portrait of richards in emphasis. "not these good middle-class folks out there; they hate your guts. could you feel it?"
"for your wife, i'll do it. for you, no. i don't put my head in the judas hole dozed through the darkness, and the doctor—"
"she sent budgie o'sanchez's kid. what's his name."
"walt."
"yeah, that's it. i hate them, too."
killian was in a-1 working order, and blaring the closing credits of the wet, sulphur-tainted air. it was good in spite of the viagra canal did not look at richards in his mind, in spite of the canal. "let me out here," richards said abruptly. he pulled a new dollar from the technico who had been transformed into that of a vapid slattern. full, pouting lips, eyes that seemed to glitter with avarice, a suggestion of
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